MR prefrontal cortex volumetry by stereology can yield accurate and repeatable measurements. The use of specific internal landmarks to define prefrontal cortex boundaries on 3D images was critical to obtaining accurate measurements. The overall 3-way inter- rater ICC equals 0.95 intra-rater ICCs equals 0.95 - 0.98. This study was designed to compare computer-assisted histomorphometric analysis (CAHA) and stereology (STER) as measurement tools for evaluating the repair response during periodontal wound healing. Stereological measurement yielded high repeatability and precision, and was time efficient for the raters. It is a multidisciplinary science field dealing with the three-dimensional. Prefrontal cortex volumes were defined as all sections of the frontal lobe anterior to the anterior commissure. Stereology (from the Greek stereos solid) is considered as the spatial interpretation of profiles seen in sections. In addition images were resliced into coronal sections perpendicular to the bicommissural plane. Fixed grid stereologic methods were used to estimate prefrontal cortex volumes on a graphic workstation, after the images are scaled from 16 to 8 bits using a histogram method.
Stereological methods were tested by a blinded comparison of measurements applied to 3D MR scans obtained using an MPRAGE protocol. A semiautomated method with quantitative characterization of its performance is sought to reliably distinguish small prefrontal cortex volume changes within individuals and between groups. Prefrontal cortex volumetry by brain magnetic resonance (MR) is required to estimate changes postulated to occur in certain psychiatric and neurologic disorders. MRI volumetry of prefrontal cortex MRI volumetry of prefrontal cortex
0 kommentar(er)
